Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497637 | 0.78 | CYP1A2 (0.40) | CTDSP1CYP1A2MAPTCYP3A4CYP2D6 | |
| SCHEMBL26690060 | 0.78 | LMNA (0.42) | CTDSP1CYP1A2MAPTMAPK1CYP2C19 | |
| SCHEMBL361412 | 0.76 | POLB (0.43) | CTDSP1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL28413058 | 0.76 | RAB9A (0.43) | CTDSP1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL11533493 | 0.75 | KMT2A (0.51) | MAPTALDH1A1LMNAKDM4EPOLB | |
| SCHEMBL25377449 | 0.74 | TRPM8 (0.57) | CTDSP1MAPTALDH1A1LMNAKDM4E | |
| SCHEMBL27658592 | 0.73 | NPSR1 (0.50) | MAPTMAPK1ALDH1A1LMNAKDM4E | |
| SCHEMBL11441996 | 0.70 | ALDH1A1 (0.48) | CYP1A2MAPTCYP2C19ALDH1A1LMNA | |
| SCHEMBL25377148 | 0.70 | TRPM8 (0.44) | CTDSP1CYP1A2ALDH1A1KDM4EPOLB | |
| SCHEMBL25376566 | 0.70 | TRPM8 (0.52) | MAPTALDH1A1LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619086-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20080139579-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-06-12 | — | — | US | disclosed |
| EP-1725535-A2 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005086700-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139579-A1 | Hiv Integrase Inhibitors | INTS9, CDK9, PRDM9 | CTDSP1 676/4885CYP1A2 2511/4885MAPT 2898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.