Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.49 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.47 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | ATM | Q13315 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4500298 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| SCHEMBL4488404 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| SCHEMBL6944191 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| SCHEMBL29783956 | 0.76 | KDM4E (0.70) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| Fumaric Acid SCHEMBL6187286 | 0.75 | SIGMAR1 (0.54) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| Fumaric Acid SCHEMBL6187283 | 0.75 | SIGMAR1 (0.54) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| Trifluoroacetic Acid SCHEMBL19613524 | 0.74 | DRD2 (0.49) | ALDH1A1KMT2AMEN1SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL19613522 | 0.74 | DRD2 (0.49) | ALDH1A1KMT2AMEN1SIGMAR1 | |
| Formic Acid SCHEMBL28291907 | 0.73 | KDM4E (0.54) | KDM4EALDH1A1ATMTDP1NPSR1 | |
| SCHEMBL15859937 | 0.73 | KDM4E (0.63) | KDM4EALDH1A1ATMTDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619096-B2 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | SLC6A2, SLC6A3, SLC18A2 | KMT2A 3131/4885MEN1 1606/4885SLC6A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.