SCHEMBL450084

SCHEMBL450084

CC(C)(C)c1ccc(C(=O)CC(=O)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.85
NPC1 O15118 3/20 0.85
MAPT P10636 2/20 0.85
LMNA P02545 4/20 0.76
ALDH1A1 P00352 2/20 0.76
RECQL P46063 2/20 0.76
MAPK1 P28482 2/20 0.76
ALOX15 P16050 1/20 0.76
APEX1 P27695 1/20 0.76
HSD17B10 Q99714 1/20 0.76
TDP1 Q9NUW8 1/20 0.76
HDAC1 Q13547 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.61
HTT P42858 1/20 0.61
KCNH2 Q12809 1/20 0.61
SRD5A2 P31213 1/20 0.55
POLB P06746 1/20 0.55
TP53 P04637 1/20 0.53
HPGD P15428 1/20 0.53
NFKB1 P19838 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7090275 0.92 NPC1 (1.00) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL268855 0.92 RAB9A (0.73) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL1904124 0.92 MAPT (0.73) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL1177177 0.91 RAB9A (0.72) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL4828018 0.90 RAB9A (0.71) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL13550744 0.90 RAB9A (0.71) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL13550716 0.90 NPC1 (0.71) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL1177079 0.90 RAB9A (0.70) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL12017412 0.89 RAB9A (0.69) RAB9ANPC1MAPTLMNAALDH1A1
SCHEMBL11021332 0.89 LMNA (0.73) RAB9ANPC1MAPTLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 487 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935490-B1 ORGANOPOLYSILOXANE COMPOSITION SUITABLE FOR VULCANISATION INTO AN ELASTOMER AT ROOM TEMPERATURE AND NEW ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS ELKEM SILICONES FRANCE SAS (FR) 2022-12-21 EP claimed
CN-107075120-B Silicone composition crosslinking catalyst 埃肯有机硅法国有限公司 2021-02-26 CN claimed
EP-3385304-B1 ORGANOPOLYSILOXANE COMPOSITION WHICH CAN BE VULCANISED AT AMBIENT TEMPERATURE IN ELASTOMER ELKEM SILICONES FRANCE SAS (FR) 2020-07-15 EP claimed
US-10308770-B2 Silicone composition crosslinking catalysts ELKEN SILICONES FRANCE SAS (FR) 2019-06-04 US claimed
US-10196488-B2 Silicone composition crosslinking catalysts ELKEM SILICONES FRANCE SAS (FR) 2019-02-05 US claimed
EP-3215556-B1 NOVEL SILICONE COMPOSITION CROSSLINKING CATALYSTS ELKEM SILICONES FRANCE SAS (FR) 2018-10-17 EP claimed
EP-2222756-B1 ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS ELKEM SILICONES FRANCE SAS (FR) 2018-10-17 EP claimed
EP-3385304-A1 ORGANOPOLYSILOXANE COMPOSITION WHICH CAN BE VULCANISED AT AMBIENT TEMPERATURE IN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS ELKEM SILICONES France SAS (FR) 2018-10-10 EP claimed
US-20180273690-A1 NOVEL SILICONE COMPOSITION CROSSLINKING CATALYSTS BLUESTAR SILICONES FRANCE SAS (FR) 2018-09-27 US claimed
EP-3215557-B1 NOVEL SILICONE COMPOSITION CROSSLINKING CATALYSTS ELKEM SILICONES FRANCE SAS (FR) 2018-09-26 EP claimed
JP-2011506741-A 2011-03-03 JP claimed
US-20110046304-A1 ROOM TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS BLUESTAR SILICONES FRANCE (FR) 2011-02-24 US claimed
US-20110040034-A1 ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS BLUESTAR SILICONES FRANCE SAS (DE) 2011-02-17 US claimed
US-20110021684-A1 RTV-ORGANOPOLYSILOXANE COMPOSITIONS AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS THEREFOR BLUESTAR SILICONES FRANCE (FR) 2011-01-27 US claimed
US-20100324213-A1 RTV-ORGANOPOLYSILOXANE COMPOSITIONS AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS THEREFOR BLUESTAR SILICONES FRANCE (FR) 2010-12-23 US claimed
EP-2222626-A1 ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS Bluestar Silicones France (FR) 2010-09-01 EP claimed
EP-2222771-A1 ORGANOPOLYSILOXANE COMPOSITION ROOM TEMPERATURE VULCANIZABLE TO ELASTOMER AND NEW ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS Bluestar Silicones France (FR) 2010-09-01 EP claimed
WO-2010043354-A1 NOVEL CATALYSTS FOR THE REACTION BETWEEN AN ISOCYANATE AND AN ALCOHOL BLUESTAR SILICONES FRANCE (FR) 2010-04-22 WO claimed
WO-2009106722-A1 ORGANOPOLYSILOXANE COMPOSITION ROOM TEMPERATURE VULCANIZABLE TO ELASTOMER AND NEW ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS BLUESTAR SILICONES FRANCE (FR) 2009-09-03 WO claimed
WO-2009106718-A1 ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS BLUESTAR SILICONES FRANCE (FR) 2009-09-03 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046304-A1 ROOM TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS COLGALT1, ARSA, IDUA RAB9A 4731/4885NPC1 3775/4885MAPT 3270/4885
US-20110040034-A1 ROOM-TEMPERATURE VULCANISABLE ORGANOPOLYSILOXANE COMPOUND TO GIVE AN ELASTOMER AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS COLGALT1, IDUA, ARSA RAB9A 4756/4885NPC1 3929/4885MAPT 3574/4885
US-20100324213-A1 RTV-ORGANOPOLYSILOXANE COMPOSITIONS AND NOVEL ORGANOPOLYSILOXANE POLYCONDENSATION CATALYSTS THEREFOR IDUA, MAN2B1, RNASE1 RAB9A 4156/4885NPC1 3308/4885MAPT 3815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.