Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221779 | 0.85 | RAB9A (0.65) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL6591553 | 0.84 | MEN1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL14345211 | 0.84 | ALDH1A1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL12700389 | 0.83 | MAPT (0.65) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18132534 | 0.81 | TAS1R3 (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL18132529 | 0.78 | TAS1R3 (0.54) | KMT2ASMN1; SMN2ALDH1A1RAB9AGAA | |
| SCHEMBL11592283 | 0.76 | HPGD (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL13163081 | 0.76 | POLB (0.70) | KMT2ASMN1; SMN2ALDH1A1RAB9AGAA | |
| SCHEMBL1663714 | 0.75 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL15871961 | 0.75 | SMN1; SMN2 (0.61) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082365-A1 | Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists | NOVARTIS AG | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082365-A1 | Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists | TRPV1, TRPV3, TRPV5 | MEN1 4252/4885KMT2A 3561/4885SMN1; SMN2 4016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.