SCHEMBL450499

SCHEMBL450499

Clc1cc(Cl)c(Br)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
TSHR P16473 7/20 0.47
HSD17B10 Q99714 5/20 0.47
CYP3A4 P08684 5/20 0.47
RECQL P46063 3/20 0.47
HPGD P15428 3/20 0.41
AHR P35869 3/20 0.41
TP53 P04637 3/20 0.40
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
MAPT P10636 2/20 0.36
ALOX15 P16050 2/20 0.36
ALOX12 P18054 2/20 0.36
MAPK1 P28482 2/20 0.36
CASP1 P29466 2/20 0.36
CASP7 P55210 2/20 0.36
KMT2A Q03164 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
SLC22A2 O15244 1/20 0.36
SLC22A1 O15245 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18686817 0.84 ALDH1A1 (0.45) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL22175345 0.80 ALDH1A1 (0.41) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL28965365 0.80 ALDH1A1 (0.41) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL13550044 0.80 RAPGEF4 (0.43) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL10616362 0.79 TTR (0.47) ALDH1A1TSHRCYP3A4AHRMAPK1
SCHEMBL29090318 0.79 NMT1 (0.46) ALDH1A1TSHRCYP3A4AHRMEN1
Hydrochloric Acid SCHEMBL30562830 0.78 TSHR (0.42) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL3525581 0.76 ALDH1A1 (0.38) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL9603854 0.76 GABRA1 (0.54) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL3524890 0.74 AKR1C4 (0.63) ALDH1A1TSHRHSD17B10CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117069611-A Preparation method of 1- (2, 4, 6-trichlorophenyl) propan-2-one O-methyl oxime 浙江工业大学 2023-11-17 CN claimed
CN-113024412-A Preparation method of 2,4, 6-trichlorobenzonitrile 上海立科化学科技有限公司 2021-06-25 CN claimed
CN-120040328-A Silver phenylchalcodate quantum dot, preparation method thereof and light-emitting device 广东聚华新型显示研究院 2025-05-27 CN disclosed
CN-118666765-A Triazole alcohol compound, and preparation method and application thereof 中国人民解放军海军军医大学 2024-09-20 CN disclosed
CN-117069611-A Preparation method of 1- (2, 4, 6-trichlorophenyl) propan-2-one O-methyl oxime 浙江工业大学 2023-11-17 CN disclosed
CN-117069611-A Preparation method of 1- (2, 4, 6-trichlorophenyl) propan-2-one O-methyl oxime 浙江工业大学 2023-11-17 CN disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
CN-113372195-A Preparation method of phloroglucinol 海口天行健药物研究有限公司 2021-09-10 CN disclosed
CN-113024412-A Preparation method of 2,4, 6-trichlorobenzonitrile 上海立科化学科技有限公司 2021-06-25 CN disclosed
WO-2005044812-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS WYETH A CORPORATION OF THE STATE OF DELAWARE (US) 2005-05-19 WO disclosed
EP-1002788-B1 Process for preparing halogenated phenylmalonates BASF AG (DE) 2004-03-10 EP disclosed
US-6242451-B1 Fungicidal trihalophenyl-triazolopyrimidines BASF AKTIENGESELLSCHAFT 2001-06-05 US disclosed
US-6156925-A Process for the preparation of halogenated phenylmaloates AMERICAN CYANAMID COMPANY (US) 2000-12-05 US disclosed
EP-1002788-A1 Process for preparing halogenated phenylmalonates American Cyanamid Company (US) 2000-05-24 EP disclosed
US-5985883-A FUNGICIDAL ACTIVITY AGAINST RICE BLAST DISEASE AMERICAN CYANAMID COMPANY (US) 1999-11-16 US disclosed
EP-0109606-B1 PROCESS FOR THE FORMYLATION OF ARYL HALIDES BAYER AG (DE) 1986-01-22 EP disclosed
US-4536344-A USING A PHOSPINE OR PHOSPHITE BAYER AKTIENGESELLSCHAFT (DE) 1985-08-20 US disclosed
EP-0109606-A1 Process for the formylation of aryl halides BAYER AG (DE) 1984-05-30 EP disclosed