Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508586 | 0.82 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3246733 | 0.71 | ALDH1A1 (0.45) | NPC1ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL12065054 | 0.69 | CCNC (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13075670 | 0.69 | PDE2A (0.44) | CXCR2PDE2AMAPK1RPS6KA1HTT | |
| SCHEMBL4504228 | 0.68 | CRHR1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3247676 | 0.66 | IL1B (0.40) | NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL4492347 | 0.65 | ENPP2 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8038788 | 0.65 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8057713 | 0.63 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12297021 | 0.63 | CYP3A4 (0.50) | MAPK1HTTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | CFTR, PKD1, PKD2 | PSEN1 3768/4885PSEN2 4111/4885APH1B 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.