SCHEMBL450654

SCHEMBL450654

CC(C)(C)[Si](Cl)(Cl)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.36
SLC6A2 P23975 1/20 0.36
ESR1 P03372 3/20 0.34
ESR2 Q92731 3/20 0.34
LMNA P02545 2/20 0.33
MAPK1 P28482 1/20 0.33
CYP2D6 P10635 1/20 0.33
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
TSHR P16473 4/20 0.32
ALDH1A1 P00352 2/20 0.31
ALOX15 P16050 1/20 0.31
AKT1 P31749 1/20 0.31
AKT2 P31751 1/20 0.31
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
ATM Q13315 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL707010 0.86 NR1H2 (0.32) NR1H2NR1H3
SCHEMBL708403 0.79 ESR1 (0.34) TAAR1SLC6A2ESR1ESR2LMNA
SCHEMBL28069640 0.79 ESR1 (0.34) TAAR1SLC6A2ESR1ESR2LMNA
SCHEMBL4241 0.79 ESR1 (0.34) TAAR1SLC6A2ESR1ESR2LMNA
SCHEMBL10630519 0.78 MAPK1 (0.39) TAAR1ESR1ESR2MAPK1NR1H2
SCHEMBL27840073 0.77 ESR1 (0.33) TAAR1SLC6A2ESR1ESR2MAPK1
SCHEMBL1314801 0.77 ESR1 (0.38) TAAR1SLC6A2ESR1ESR2MAPK1
SCHEMBL6391397 0.77 ESR1 (0.33) TAAR1SLC6A2ESR1ESR2MAPK1
SCHEMBL7752250 0.75 CYP1A2 (0.32) ESR1ESR2MAPK1CYP2D6NR1H2
SCHEMBL2492802 0.75 ESR1 (0.32) ESR1ESR2MAPK1NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115850340-B Eugenol-based silicon-containing flame retardant, and preparation method and application thereof 江南大学 2023-11-28 CN claimed
CN-115850340-A Eugenol-based silicon-containing flame retardant and preparation method and application thereof 江南大学 2023-03-28 CN claimed
US-20130153263-A1 INORGANIC NANOFILLER, PARTIAL DISCHARGE RESISTANT ENAMELED WIRE INCLUDING THE SAME, AND PREPARING METHOD OF THE ENAMELED WIRE SEJONG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION (KR) 2013-06-20 US claimed
EP-1546250-B1 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA DOW CORNING (US) 2007-12-19 EP claimed
CN-1305948-C Organosilicon compounds and blends for treating silica DOW CORNING (US) 2007-03-21 CN claimed
CN-1681880-A Organosilicon compounds and blends for treating silica DOW CORNING (US) 2005-10-12 CN claimed
EP-1546250-A2 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA Dow Corning Corporation (US) 2005-06-29 EP claimed
WO-2004024812-A2 ORGANOSILICON COMPOUNDS AND BLENDS FOR TREATING SILICA DOW CORNING CORPORATION (US) 2004-03-25 WO claimed
EP-3782599-B1 DENTAL POLYMERIZABLE COMPOSITION BASED ON CONDENSED SILANES VOCO GMBH (DE) 2025-09-17 EP disclosed
US-12109812-B2 Ink jet printing method and ink jet printing apparatus SEIKO EPSON CORPORATION (JP) 2024-10-08 US disclosed
WO-2024149694-A1 NITROGENOUS HETEROCYCLES FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-07-18 WO disclosed
US-11992538-B2 Polymerizable dental composition based on condensed silanes VOCO GMBH (DE) 2024-05-28 US disclosed
WO-2024094592-A2 NITROGENOUS HETEROCYCLES FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-05-10 WO disclosed
CN-115850340-B Eugenol-based silicon-containing flame retardant, and preparation method and application thereof 江南大学 2023-11-28 CN disclosed
US-4923719-A ORGANOFLUOROSILANE ALLIED-SIGNAL INC. (US) 1990-05-08 US disclosed
WO-1990002107-A1 A METHOD OF COATING SILICON CARBIDE FIBERS ALLIED-SIGNAL INC. (US) 1990-03-08 WO disclosed
US-4822716-A FINE PATTERN SEMICONDUCTOR, INTEGRATED CIRCUIT KABUSHIKI KAISHA TOSHIBA (JP) 1989-04-18 US disclosed
EP-0231497-A1 Silicone resist materials containing polysiloxanes KABUSHIKI KAISHA TOSHIBA (JP) 1987-08-12 EP disclosed
US-4491669-A Mixed alkoxyaminosilanes, methods of making same and vulcanizing silicons prepared therefrom PETRARCH SYSTEMS INC. (US) 1985-01-01 US disclosed
US-4307212-A Curable epoxy resins GENERAL ELECTRIC COMPANY (US) 1981-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11992538-B2 Polymerizable dental composition based on condensed silanes NCAPH, RCC1, NCAPD2 TAAR1 2152/4885SLC6A2 4623/4885ESR1 755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.