Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRND | Q07001 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708885 | 0.85 | HDAC1 (0.42) | MAPTALDH1A1SLC6A3KMT2AMEN1 | |
| SCHEMBL29145551 | 0.84 | CES2 (0.44) | CES2CES1MAPTALDH1A1MME | |
| SCHEMBL27876499 | 0.84 | CES2 (0.46) | CES2CES1MAPTALDH1A1MME | |
| SCHEMBL29100776 | 0.83 | CES2 (0.42) | CES2CES1MAPTALDH1A1MME | |
| SCHEMBL31560842 | 0.82 | PTGS1 (0.50) | CES2CES1MAPTCHRNA1CHRNG | |
| SCHEMBL1565587 | 0.81 | CES2 (0.44) | CES2CES1MAPTALDH1A1CHRNA1 | |
| SCHEMBL5661276 | 0.81 | CES2 (0.44) | CES2CES1MAPTALDH1A1CHRNA1 | |
| SCHEMBL30968933 | 0.81 | CES2 (0.44) | CES2CES1MAPTALDH1A1CHRNA1 | |
| SCHEMBL7976506 | 0.80 | SMN1; SMN2 (0.47) | MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL25243247 | 0.78 | MAPT (0.44) | CES2CES1MAPTALDH1A1CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | claimed |
| CN-116947638-A | Method for preparing sitagliptin intermediate by one-pot method | 淄博飞源化工有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-115246762-A | Preparation method of 2,4,5-trifluorophenylacetic acid | 上海朴颐化学科技有限公司 | 2022-10-28 | — | — | CN | disclosed |
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | BROWN REBECCA ELIZABETH | 2009-12-03 | — | — | US | disclosed |
| EP-1881988-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122200-A1 | 2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | TRPV1, TRPV2, TRPV4 | CES2 2849/4885CES1 1580/4885MAPT 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.