SCHEMBL7708885

SCHEMBL7708885

COC(=O)C(F)c1ccc(N)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39
CA5A P35218 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
CA5B Q9Y2D0 1/20 0.39
ALDH1A1 P00352 4/20 0.37
SLC6A3 Q01959 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 4/20 0.36
DPP4 P27487 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4507232 0.85 CES2 (0.45) ALDH1A1SLC6A3KMT2AMEN1MAPT
SCHEMBL24875457 0.84 MT-CO2 (0.47) HDAC1HDAC6KMT2AMEN1MAPT
SCHEMBL30192791 0.84 MT-CO2 (0.47) HDAC1HDAC6KMT2AMEN1MAPT
SCHEMBL8476208 0.84 MT-CO2 (0.47) HDAC1HDAC6KMT2AMEN1MAPT
SCHEMBL2433161 0.84 MT-CO2 (0.38) CA12CA1CA2CA7CA9
SCHEMBL3711505 0.81 HDAC1 (0.41) HDAC1HDAC6ALDH1A1SLC6A3KMT2A
SCHEMBL7976546 0.81 ALDH1A1 (0.51) CA12CA1CA2CA7CA9
SCHEMBL27972751 0.80 AKR1C3 (0.43) HDAC1HDAC6DPP4FOLH1
SCHEMBL7714952 0.78 SLC6A3 (0.46) CA12CA1CA2CA9ALDH1A1
SCHEMBL3446364 0.73 ALDH2 (0.46) HDAC1HDAC6ALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865421-B1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LTD (GB) 2002-03-27 EP disclosed
US-6048872-A DIETETICS; ANTIDIABETIC AGENTS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS GLAXO WELLCOME INC. (US) 2000-04-11 US disclosed
EP-0865421-A1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LIMITED (GB) 1998-09-23 EP disclosed
WO-1997021665-A1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LIMITED (GB) 1997-06-19 WO disclosed