SCHEMBL4508271

SCHEMBL4508271

COc1ccc(C(=O)ON2C(=O)CCC2=O)cc1N1C(=O)C=CC1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.44
MAPT P10636 4/20 0.42
ALDH1A1 P00352 2/20 0.42
HSP90AA1 P07900 2/20 0.42
CACNA1B Q00975 2/20 0.42
APBA1 Q02410 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
PKM P14618 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
CCR6 P51684 1/20 0.42
APOBEC3G Q9HC16 1/20 0.42
G6PD P11413 1/20 0.42
TLR9 Q9NR96 1/20 0.42
KMT2A Q03164 6/20 0.38
SMN1; SMN2 Q16637 3/20 0.36
POLB P06746 2/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
HTT P42858 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4510376 0.90 G6PD (0.51) MGLLMAPTALDH1A1HSP90AA1CACNA1B
SCHEMBL17301093 0.85 KMT2A (0.38) ALDH1A1HSP90AA1CACNA1BAPBA1NPSR1
SCHEMBL11038736 0.83 TSHR (0.53) MAPTALDH1A1MAPK1RAB9AKMT2A
SCHEMBL4520450 0.81 ALDH1A1 (0.34) MAPTALDH1A1HSP90AA1CACNA1BAPBA1
SCHEMBL4809444 0.79 ALDH1A1 (0.56) MAPTALDH1A1NPSR1RAB9ASMN1; SMN2
SCHEMBL6553052 0.79 MAPT (0.46) MAPTALDH1A1MAPK1RAB9AKMT2A
SCHEMBL9225912 0.79 HSD17B2 (0.42) MAPTMAPK1KMT2ASMN1; SMN2POLB
SCHEMBL6553048 0.78 KMT2A (0.55) MAPTALDH1A1HSP90AA1RAB9AKMT2A
SCHEMBL4518269 0.78 PTGS1 (0.48) MGLLMAPTALDH1A1HSP90AA1CACNA1B
SCHEMBL4807790 0.76 HTR4 (0.46) MAPTALDH1A1RAB9ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090305264-A1 COOPERATIVE PROBES AND METHODS OF USING THEM FLUIDIGM CORPORATION 2009-12-10 US disclosed
EP-2004861-A2 COOPERATIVE PROBES AND METHODS OF USING THEM Arcxis Biotechnologies, Inc. (US) 2008-12-24 EP disclosed
EP-1893741-A1 CELL-BASED MICROARRAYS, AND METHODS FOR THEIR PREPARATION AND USE Beckman Coulter, Inc. (US) 2008-03-05 EP disclosed
WO-2007114986-A2 COOPERATIVE PROBES AND METHODS OF USING THEM ARCXIS BIOTECHNOLOGIES, INC. (US) 2007-10-11 WO disclosed
WO-2007001817-A1 CELL-BASED MICROARRAYS, AND METHODS FOR THEIR PREPARATION AND USE BECKMAN COULTER, INC. (US) 2007-01-04 WO disclosed
US-20060292559-A1 Cell-based microarrays, and methods for their preparation and use BECKMAN COULTER, INC. (US) 2006-12-28 US disclosed
EP-0779934-B1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN COULTER INC (US) 2000-04-05 EP disclosed
US-5648213-A IMMUNOASSAY BECKMAN INSTRUMENTS, INC. (US) 1997-07-15 US disclosed
EP-0779934-A1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN INSTRUMENTS, INC. (US) 1997-06-25 EP disclosed
WO-1996006948-A1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN INSTRUMENTS, INC. (US) 1996-03-07 WO disclosed