Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27543705 | 0.89 | USP2 (0.40) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| Hydrochloric Acid SCHEMBL30534850 | 0.80 | CA1 (0.41) | ALDH1A1SMN1; SMN2CA2POLBMEN1 | |
| Hydrochloric Acid SCHEMBL27843998 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| SCHEMBL1038127 | 0.79 | ACHE (0.58) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| SCHEMBL3668976 | 0.79 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| Hydrochloric Acid SCHEMBL27535396 | 0.78 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| Hydrochloric Acid SCHEMBL27481294 | 0.78 | RBP4 (0.40) | PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL27482054 | 0.78 | LMNA (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL4534465 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2ACHECA2POLB | |
| SCHEMBL29367415 | 0.76 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ACHECA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1974611-A | Prepn and application of catalytic nucleating agent for polyolefin | EAST CHINA UNIV OF SCIENCE & T (CN) | 2007-06-06 | — | — | CN | claimed |
| WO-2013047891-A2 | WASHING METHOD, ADDITION POLYMERIZATION METHOD, PREPOLYMERIZATION METHOD, PREPOLYMERIZED CATALYTIC COMPONENT FOR ADDITION POLYMERIZATION, AND METHOD FOR PRODUCING ADDITION POLYMER USING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-04-04 | — | — | WO | disclosed |
| CN-101255214-B | Diene polymer and process for producing the same | SUMITOMO CO LTD | 2013-01-02 | — | — | CN | disclosed |
| CN-102653570-A | Prepolymerization method, prepolymerized catalyst component for addition polymerization, and method for producing addition polymer using the same | SUMITOMO CHEMICAL CO | 2012-09-05 | — | — | CN | disclosed |
| CN-102652140-A | Olefin polymerization catalyst and process for producing olefin polymer | SUMITOMO CHEMICAL CO | 2012-08-29 | — | — | CN | disclosed |
| WO-2012063972-A1 | METHOD FOR COATING REACTOR | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-05-18 | — | — | WO | disclosed |
| US-20090227746-A1 | Processes for producing a catalyst component for addition polymerization, a catalyst and an addition polymer | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| CN-101525395-A | Processes for producing a catalyst component for addition polymerization, a catalyst and an addition polymer | SUMITOMO CHEMICAL CO | 2009-09-09 | — | — | CN | disclosed |
| CN-101429257-A | Modified particle and its manufacturing method, carrier, catalyst component for addition polymerization, catalyst for addition polymerization and manufacturing method of addition polymer | SUMITOMO CHEMICAL CO (JP) | 2009-05-13 | — | — | CN | disclosed |
| CN-100422219-C | Polyaddition catalyst component, polyaddition catalyst and process for preparing addition polymer | SUMITOMO CHEMICAL CO (JP) | 2008-10-01 | — | — | CN | disclosed |
| CN-1517368-A | Metal compound, catalyst component and catalyst for addition polymerization, and process for producing addition polymer | ס�ѻ�ѧ��ҵ��ʽ���� | 2004-08-04 | — | — | CN | disclosed |
| CN-1496996-A | Modified granular, addition polymerized catalyst composition, addition polymerization catalyst and method of producing addition polymerization product | ס�ѻ�ѧ��ҵ��ʽ���� | 2004-05-19 | — | — | CN | disclosed |
| CN-1130389-C | Modified aluminium-oxygen base compound, polymerizing catalyst, and process for producing olefine polymer and alkenyl aromatic hydrocarbon polymer | SUMITOMO CHEMICAL CO (JP) | 2003-12-10 | — | — | CN | disclosed |
| CN-1422286-A | Modified particle, support, catalyst component for addition polymerization, catalyst for addition polymerization, and process for producing addition polymer | SUMITOMO CHEMICAL CO (JP) | 2003-06-04 | — | — | CN | disclosed |
| CN-1306011-A | Polyaddition catalyst component, polyaddition catalyst and method for preparing addition polymer | SUMITOMO CHEMICAL CO (JP) | 2001-08-01 | — | — | CN | disclosed |
| CN-1303872-A | Component of polyaddition catalyst, polyaddition catalyst and process for preparing addition polymer | SUMITOMO CHEMICAL CO (JP) | 2001-07-18 | — | — | CN | disclosed |
| CN-1248584-A | Modified aluminium-oxygen base compound, polymerizing catalyst, and process for producing olefine polymer and alkenyl aromatic hydrocarbon polymer | SUMITOMO CHEMICAL CO (JP) | 2000-03-29 | — | — | CN | disclosed |
| US-6034190-A | COORDINATION CATALYST | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-03-07 | — | — | US | disclosed |
| CN-1224026-A | Catalyst component for polymerizing ethylenically unsaturated monomers, catalyst and method of use thereof | MITSUI CHEMICALS INC (JP) | 1999-07-28 | — | — | CN | disclosed |
| CN-1151409-A | Olefin polymerizationc atalyst component, olefin polymerizationc atalyst and producing olefin polymer | SUMITOMO CHEMICAL CO (JP) | 1997-06-11 | — | — | CN | disclosed |