Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | CTSV | O60911 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | GHSR | Q92847 | 3/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056367 | 0.82 | GABRA1 (0.48) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL7282642 | 0.80 | ALDH1A1 (0.42) | GABRA1GABRB2 | |
| SCHEMBL4531377 | 0.78 | HTR1A (0.50) | HTR1AHTR1DHTR1BGPR84GABRA1 | |
| SCHEMBL4531373 | 0.78 | HTR1A (0.50) | HTR1AHTR1DHTR1BGPR84GABRA1 | |
| SCHEMBL6629875 | 0.78 | HDAC1 (0.57) | HTR1AHTR1DHTR1BGPR84 | |
| SCHEMBL564963 | 0.76 | HDAC1 (0.56) | HTR1AHTR1DHTR1BGPR84 | |
| SCHEMBL20382323 | 0.75 | GHSR (0.64) | HTR1AHTR1DHTR1BGPR84CTSV | |
| SCHEMBL532789 | 0.75 | HTR1A (0.55) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL2421287 | 0.74 | GPR84 (0.54) | GPR84 | |
| SCHEMBL12100781 | 0.74 | HTR1A (0.57) | HTR1AHTR1DHTR1BCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103007-A2 | STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-08-20 | — | — | WO | disclosed |