Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510715 | 0.95 | SOAT1 (0.52) | SOAT1ALDH1A1TSHRKDM4EENPP1 | |
| SCHEMBL1704629 | 0.92 | SOAT1 (0.64) | SOAT1TSHRLMNAMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL1704598 | 0.91 | SOAT1 (0.64) | SOAT1TSHRLMNAMAPTNPC1 | |
| SCHEMBL1704605 | 0.91 | SOAT1 (0.51) | SOAT1ALDH1A1TSHRKDM4EENPP1 | |
| Hydrochloric Acid SCHEMBL1704617 | 0.90 | SOAT1 (0.51) | SOAT1ALDH1A1TSHRKDM4EENPP1 | |
| SCHEMBL14502991 | 0.90 | SOAT1 (0.49) | SOAT1ALDH1A1TSHRKDM4EENPP1 | |
| SCHEMBL14503004 | 0.81 | SOAT1 (0.51) | SOAT1ALDH1A1TSHRKDM4EENPP1 | |
| SCHEMBL4506878 | 0.79 | KDM4E (0.42) | SOAT1ALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL1704650 | 0.79 | SOAT1 (0.63) | SOAT1ALDH1A1SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL1705124 | 0.78 | SOAT1 (0.62) | SOAT1ALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223764-B2 | 2,4-bis (trifluoroethoxy)pyridine compound and drug containing the compound | KOWA CO., LTD. (JP) | 2007-05-29 | — | — | US | claimed |
| EP-1642899-B1 | 2,4-BIS(TRIFLUOROETHOXY)PYRIDINE COMPOUND AND MEDICINE CONTAINING THE SAME | KOWA CO (JP) | 2012-08-15 | — | — | EP | disclosed |
| US-7560547-B2 | Hydroxyalkyl cyclic diamine compounds | KOWA CO., LTD. (JP) | 2009-07-14 | — | — | US | disclosed |
| US-7223764-B2 | 2,4-bis (trifluoroethoxy)pyridine compound and drug containing the compound | KOWA CO., LTD. (JP) | 2007-05-29 | — | — | US | disclosed |
| US-20070088159-A1 | HYDROXYALKYL CYCLIC DIAMINE COMPOUNDS | KOWA CO., LTD. (JP) | 2007-04-19 | — | — | US | disclosed |
| US-7176306-B2 | Hydroxyalkyl cyclic diamine compound | KOWA CO., LTD. (JP) | 2007-02-13 | — | — | US | disclosed |
| EP-1642899-A1 | 2,4-BIS(TRIFLUOROETHOXY)PYRIDINE COMPOUND AND MEDICINE CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2006-04-05 | — | — | EP | disclosed |
| EP-1571144-A1 | HYDROXYALKYLATED CYCLIC DIAMINE COMPOUND | Kowa Co., Ltd. (JP) | 2005-09-07 | — | — | EP | disclosed |
| US-20050020606-A1 | 2,4-Bis (trifluoroethoxy)pyridine compound and drug containing the compound | KOWA CO., LTD. (JP) | 2005-01-27 | — | — | US | disclosed |
| US-20040176593-A1 | Hydroxyalkyl cyclic diamine compound | KOWA CO., LTD. (JP) | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020606-A1 | 2,4-Bis (trifluoroethoxy)pyridine compound and drug containing the compound | ACAT2, ACAT1, CYP7A1 | SOAT1 223/4885ALDH1A1 586/4885TSHR 3355/4885 |
| US-20040176593-A1 | Hydroxyalkyl cyclic diamine compound | DDC, AOC1, ODC1 | SOAT1 1314/4885ALDH1A1 45/4885TSHR 4104/4885 |
| US-20070088159-A1 | HYDROXYALKYL CYCLIC DIAMINE COMPOUNDS | HDHD5, DDC, DDT | SOAT1 1023/4885ALDH1A1 146/4885TSHR 4300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.