⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511579 | 0.94 | NOS1 (0.33) | — | |
| SCHEMBL3804977 | 0.75 | — | — | |
| SCHEMBL4724871 | 0.68 | — | — | |
| SCHEMBL4749067 | 0.67 | NOS1 (0.32) | — | |
| SCHEMBL818299 | 0.66 | — | — | |
| SCHEMBL17291825 | 0.66 | HTR1A (0.39) | — | |
| SCHEMBL538845 | 0.66 | — | — | |
| SCHEMBL4721777 | 0.65 | GNAI3 (0.34) | — | |
| SCHEMBL4723708 | 0.65 | — | — | |
| SCHEMBL9836904 | 0.65 | KMT2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004653-B1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-A]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-12-30 | — | — | EP | claimed |
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | claimed |
| EP-2004653-A1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS | Novartis AG (CH) | 2008-12-24 | — | — | EP | claimed |
| WO-2007113000-A1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | claimed |
| US-20040224967-A1 | Phenylaminopyrimidine derivatives and methods of use | CHEN GUOQING P | 2004-11-11 | — | — | US | claimed |
| US-4607032-A | Quino-benoxazine antibacterial compounds | ABBOTT LABORATORIES (US) | 1986-08-19 | — | — | US | claimed |
| US-4533663-A | Quino-benzothiazine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-08-06 | — | — | US | claimed |
| EP-2004653-B1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-A]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-12-30 | — | — | EP | disclosed |
| US-20090275593-A1 | 3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors | NOVARTIS AG | 2009-11-05 | — | — | US | disclosed |
| EP-2004653-A1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007113000-A1 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| US-7232825-B2 | Phenylaminopyrimidine derivatives and methods of use | CHEN GUOQING P | 2007-06-19 | — | — | US | disclosed |
| US-20040224967-A1 | Phenylaminopyrimidine derivatives and methods of use | CHEN GUOQING P | 2004-11-11 | — | — | US | disclosed |