Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 11/20 | 1.00 |
| ▸ | CYP17A1 | P05093 | 4/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260198 | 0.84 | CYP11B2 (0.88) | CYP11B2CYP11B1CYP17A1CYP19A1 | |
| SCHEMBL29809001 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL13537172 | 0.83 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL6188982 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL30712752 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL23841405 | 0.80 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL16557755 | 0.79 | CYP11B2 (0.64) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL15172398 | 0.79 | CYP11B2 (0.66) | CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2 | |
| SCHEMBL7343284 | 0.79 | CYP11B1 (0.65) | CYP11B2CYP11B1CYP17A1CYP19A1 | |
| SCHEMBL4510935 | 0.79 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP17A1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | claimed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | claimed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | claimed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | claimed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | CYP11B1, HSD11B1, HSD17B1 | CYP11B2 5/4885CYP11B1 1/4885CYP17A1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.