Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 15/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28277763 | 0.98 | MRGPRX4 (0.58) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL27450239 | 0.90 | MRGPRX4 (0.56) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL40246 | 0.85 | CYP4F2 (0.49) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL3312463 | 0.84 | MRGPRX4 (0.60) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL30628893 | 0.84 | MRGPRX4 (0.67) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL565902 | 0.84 | MRGPRX4 (0.67) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL6000790 | 0.84 | MRGPRX4 (0.68) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL21169513 | 0.83 | LOXL2 (0.55) | MRGPRX4SMN1; SMN2RAB9AALDH1A1NPSR1 | |
| SCHEMBL11427053 | 0.83 | ALDH1A1 (0.57) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL14093309 | 0.82 | PLA2G4B (0.67) | MRGPRX4TP53PKMNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |