Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL112616 | 0.98 | CA1 (0.54) | CA1CA2CA9KIF11MAPT | |
| Biphenyl SCHEMBL710425 | 0.97 | CA1 (0.53) | CA1CA2CA9KIF11MAPT | |
| SCHEMBL2832043 | 0.90 | CA1 (0.63) | CA1CA2CA9KIF11MAPT | |
| Hydrogen Sulfide SCHEMBL16581552 | 0.88 | CA1 (0.61) | CA1CA2CA9KIF11MAPT | |
| Diphenylsulfane SCHEMBL2191112 | 0.84 | CA1 (0.50) | CA1CA2CA9KIF11MAPT | |
| SCHEMBL24360466 | 0.84 | CA2 (0.62) | CA1CA2CA9KIF11MEN1 | |
| SCHEMBL5532552 | 0.84 | CA2 (0.62) | CA1CA2CA9KIF11MEN1 | |
| Biphenyl SCHEMBL4521706 | 0.83 | CA2 (0.49) | CA1CA2CA9KIF11CXCR2 | |
| Biphenyl SCHEMBL4512202 | 0.83 | BACE1 (0.51) | CA1CA2CA9TDP1L3MBTL1 | |
| Biphenyl SCHEMBL28551760 | 0.82 | CA1 (0.53) | CA1CA2CA9KIF11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598018-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-10-06 | — | — | US | claimed |
| US-7291442-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2007-11-06 | — | — | US | claimed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | claimed |
| US-7611823-B1 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7524611-B2 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20080187862-A1 | New photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION INC. | 2008-08-07 | — | — | US | disclosed |
| US-7001708-B1 | Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-02-21 | — | — | US | disclosed |