Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255888 | 0.83 | ALDH1A1 (0.72) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL11986271 | 0.83 | MTNR1A (0.58) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL3890957 | 0.83 | MTNR1A (0.58) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL11986376 | 0.83 | ALDH1A1 (0.72) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL11210449 | 0.81 | SMN1; SMN2 (0.59) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL10969281 | 0.81 | NPC1 (0.55) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL10963231 | 0.81 | KDM4E (0.48) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL6084825 | 0.80 | NPC1 (0.54) | NPC1TP53KDM4EKMT2AMTNR1A | |
| SCHEMBL7769542 | 0.80 | HDAC3 (0.65) | NPC1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL27562982 | 0.80 | MTNR1A (0.57) | NPC1MTNR1AMTNR1BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3296302-B1 | CHIRAL SPIRO PHOSPHORUS-NITROGEN-SULPHUR TRIDENTATE LIGAND, AND PREPARATION METHOD AND APPLICATION THEREOF | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2020-02-12 | — | — | EP | disclosed |
| US-10550138-B2 | Chiral spiro phosphorus-nirogen-sulphur tridentate ligand, preparation method and application thereof | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2020-02-04 | — | — | US | disclosed |
| US-20180141966-A1 | CHIRAL SPIRO PHOSPHORUS-NIROGEN-SULPHUR TRIDENTATE LIGAND, PREPARATION METHOD AND APPLICATION THEREOF | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2018-05-24 | — | — | US | disclosed |
| EP-3296302-A1 | CHIRAL SPIRO PHOSPHORUS-NITROGEN-SULPHUR TRIDENTATE LIGAND, AND PREPARATION METHOD AND APPLICATION THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2018-03-21 | — | — | EP | disclosed |
| US-20090298889-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS | SATO PHARMACEUTICAL CO., LTD. (JP) | 2009-12-03 | — | — | US | disclosed |
| EP-1897870-A1 | PHARMACEUTICAL COMPOSITION COMPRISING 2-PYRIDONE DERIVATIVE AS ACTIVE INGREDIENT | Sato Pharmaceutical Co. Ltd. (JP) | 2008-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298889-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS | LTB4R2, LTB4R, CD4 | NPC1 3686/4885TP53 2977/4885KDM4E 3049/4885 |
| US-20180141966-A1 | CHIRAL SPIRO PHOSPHORUS-NIROGEN-SULPHUR TRIDENTATE LIGAND, PREPARATION METHOD AND APPLICATION THEREOF | TST, SPR, ROR1 | NPC1 3134/4885TP53 3403/4885KDM4E 3377/4885 |
| US-10550138-B2 | Chiral spiro phosphorus-nirogen-sulphur tridentate ligand, preparation method and application thereof | TST, SPR, ROR1 | NPC1 3134/4885TP53 3403/4885KDM4E 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.