Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518538 | 0.90 | PARP10 (0.49) | PARP11PARP10GRM5PRKACAPRKACG | |
| SCHEMBL22693586 | 0.83 | PARP10 (0.58) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL379341 | 0.78 | GRM5 (0.67) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL8323443 | 0.78 | GRM5 (0.67) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL16346860 | 0.77 | PARP10 (0.54) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL4519555 | 0.77 | PNMT (0.46) | — | |
| SCHEMBL4514434 | 0.77 | ASIC3 (0.41) | — | |
| SCHEMBL29175231 | 0.75 | PARP10 (0.52) | PARP11PARP10GRM5PARP1PDPK1 | |
| SCHEMBL30336933 | 0.73 | PRKACA (0.58) | PARP11PARP10GRM5PRKACAPRKACG | |
| SCHEMBL29261554 | 0.73 | PARP10 (0.53) | PARP11PARP10GRM5GSK3BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | IRM LLC (BM) | 2009-01-08 | — | — | US | disclosed |
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | IRM LLC (BM) | 2009-01-08 | — | — | US | disclosed |
| EP-1979347-A2 | POLYCYCLIC 1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089557-A2 | POLYCYCLIC 1, 2, 3, 4 -TETRAHYDRO- ISOQUINOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS | IRM LLC (BM) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012097-A1 | Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators | PPARG, PPARD, PPARA | PARP11 755/4885PARP10 1004/4885GRM5 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.