Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 1.00 |
| ▸ | CYP11B2 | P19099 | 12/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 9/20 | 1.00 |
| ▸ | CYP17A1 | P05093 | 1/20 | 1.00 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505824 | 0.81 | CYP11B2 (1.00) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL678667 | 0.76 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1CYP17A1ALDH1A1 | |
| SCHEMBL26785982 | 0.73 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL6825394 | 0.73 | CYP19A1 (0.57) | CYP11B1CYP11B2CYP19A1CYP17A1ALDH1A1 | |
| SCHEMBL29356366 | 0.71 | CYP11B2 (0.55) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL31083746 | 0.70 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL29537716 | 0.70 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL3819127 | 0.70 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL4167632 | 0.70 | CYP11B2 (0.54) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL16886044 | 0.69 | CYP19A1 (0.53) | CYP11B1CYP11B2CYP19A1CYP17A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | claimed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | claimed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | CYP11B1, HSD11B1, HSD17B1 | CYP11B1 1/4885CYP11B2 5/4885CYP19A1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.