Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507031 | 0.84 | SIGMAR1 (0.36) | KMT2ACYP3A4ALDH1A1MAPTHPGD | |
| SCHEMBL4511545 | 0.79 | KMT2A (0.45) | KMT2AL3MBTL1CYP3A4ALDH1A1KDM4E | |
| SCHEMBL13628885 | 0.72 | HPGD (0.43) | FKBP1ALTA4HKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL927807 | 0.71 | KMT2A (0.57) | FKBP1AKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL2583749 | 0.71 | KMT2A (0.57) | FKBP1AKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL24434796 | 0.71 | KMT2A (0.57) | FKBP1AKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL22608386 | 0.71 | FKBP1A (0.52) | FKBP1ALTA4HKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL1472792 | 0.71 | FKBP1A (0.64) | FKBP1ALTA4HKMT2AL3MBTL1CYP3A4 | |
| SCHEMBL1472793 | 0.71 | FKBP1A (0.64) | FKBP1ALTA4HKMT2AL3MBTL1CYP3A4 | |
| SCHEMBL13248928 | 0.71 | FKBP1A (0.64) | FKBP1ALTA4HKMT2AL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618983-B2 | Bicyclic triazole α4 integrin inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-11-17 | — | — | US | disclosed |
| US-20060128748-A1 | Bicyclic triazole alpha4 integrin inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-06-15 | — | — | US | disclosed |
| WO-2006052962-A2 | BICYCLIC TRIAZOLE A4 INTEGRIN INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128748-A1 | Bicyclic triazole alpha4 integrin inhibitors | ITGA4, ITGB4, ITGB5 | FKBP1A 3625/4885LTA4H 208/4885KMT2A 2094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.