Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.49 |
| ▸ | TCF4 | P15884 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509302 | 0.92 | IDO1 (0.58) | HDAC1HDAC6IDO1LMNANAMPT | |
| SCHEMBL7834456 | 0.76 | CYP11B1 (0.75) | HDAC1HDAC6IDO1LMNAALDH1A1 | |
| SCHEMBL18805043 | 0.76 | CYP11B1 (0.75) | HDAC1HDAC6IDO1LMNAALDH1A1 | |
| SCHEMBL9304316 | 0.76 | HDAC1 (0.66) | HDAC1HDAC6IDO1LMNAALDH1A1 | |
| SCHEMBL12850040 | 0.75 | HDAC6 (1.00) | HDAC1HDAC6IDO1LMNASMN1; SMN2 | |
| SCHEMBL4283175 | 0.75 | NAMPT (0.69) | NAMPTALDH1A1SMN1; SMN2MAPTTAS2R8 | |
| SCHEMBL9303096 | 0.74 | HDAC1 (0.61) | HDAC1HDAC6IDO1LMNAALDH1A1 | |
| SCHEMBL4511949 | 0.74 | HDAC1 (0.70) | HDAC1HDAC6IDO1LMNASMN1; SMN2 | |
| SCHEMBL4507749 | 0.74 | HDAC1 (0.66) | HDAC1HDAC6IDO1LMNASMN1; SMN2 | |
| SCHEMBL4490664 | 0.74 | ALDH1A1 (0.64) | LMNANAMPTALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | HDAC1 940/4885HDAC6 3583/4885IDO1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.