Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 14/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.49 |
| ▸ | WNT1 | P04628 | 3/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874232 | 0.93 | IDO1 (0.59) | IDO1HPGDSGSK3BDYRK1AWNT1 | |
| SCHEMBL972964 | 0.77 | HPGDS (0.73) | IDO1HPGDSCYP11B1CYP11B2 | |
| SCHEMBL21128683 | 0.77 | IDO1 (0.68) | IDO1HPGDSGSK3BDYRK1ACYP11B1 | |
| SCHEMBL7528332 | 0.77 | IDO1 (0.50) | IDO1HPGDSGSK3BDYRK1AWNT1 | |
| SCHEMBL20916196 | 0.76 | GSK3B (0.55) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL28035340 | 0.75 | IDO1 (0.64) | IDO1HPGDSGSK3BDYRK1ACYP11B1 | |
| SCHEMBL17559204 | 0.74 | FGFR1 (0.51) | IDO1GSK3BDYRK1AMAPK9MMP2 | |
| SCHEMBL19546668 | 0.74 | GSK3B (0.65) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL21566691 | 0.73 | IDO1 (0.62) | IDO1HPGDSGSK3BDYRK1AWNT1 | |
| SCHEMBL4979643 | 0.73 | IDO1 (0.53) | IDO1HPGDSCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | CYP11B1, HSD11B1, HSD17B1 | IDO1 913/4885HPGDS 370/4885GSK3B 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.