Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963986 | 0.88 | BAZ2B (0.43) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL862681 | 0.86 | ADORA3 (0.45) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL19186 | 0.84 | JMJD6 (0.44) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL3296730 | 0.84 | MAPT (0.39) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL2251889 | 0.84 | TSHR (0.47) | TSHRNPSR1KDM4EHSD17B10TP53 | |
| SCHEMBL28553124 | 0.81 | BAZ2B (0.46) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL3251664 | 0.80 | GAA (0.34) | TSHRKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL1862734 | 0.80 | KDM4E (0.43) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL7911428 | 0.79 | BAZ2B (0.53) | BAZ2BBAZ2AADORA3ADORA2AADORA1 | |
| SCHEMBL3267578 | 0.78 | TSHR (0.50) | BAZ2BBAZ2AADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218448-B | A kind of synthetic method of the pyrazole carboxylic acid of 1 methyl, 3 difluoromethyl 4 | 江苏恒润制药有限公司 | 2017-11-07 | — | — | CN | claimed |
| CN-105218448-A | A kind of synthetic method of 1-methyl-3-difluoromethyl-4-pyrazole carboxylic acid | Jiangsu hengrun pharmaceutical co ltd | 2016-01-06 | — | — | CN | claimed |
| CN-120118034-A | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-carboxylic acid | 辽宁龙田化工科技有限公司 | 2025-06-10 | — | — | CN | disclosed |
| CN-120118034-A | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-carboxylic acid | 辽宁龙田化工科技有限公司 | 2025-06-10 | — | — | CN | disclosed |
| CN-117447401-B | Synthesis method of difluoro pyrazole acid | 山东国邦药业有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117447401-A | Synthesis method of difluoro pyrazole acid | 山东国邦药业有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-106467492-B | preparation method of polyfluoromethyl pyrazole compound, intermediate and preparation method | 联化科技(盐城)有限公司 | 2019-12-17 | — | — | CN | disclosed |
| CN-105218448-B | A kind of synthetic method of the pyrazole carboxylic acid of 1 methyl, 3 difluoromethyl 4 | 江苏恒润制药有限公司 | 2017-11-07 | — | — | CN | disclosed |
| US-9278935-B2 | Method for preparing a fluorinated organic compound | RHODIA OPERATIONS (FR) | 2016-03-08 | — | — | US | disclosed |
| CN-105218448-A | A kind of synthetic method of 1-methyl-3-difluoromethyl-4-pyrazole carboxylic acid | Jiangsu hengrun pharmaceutical co ltd | 2016-01-06 | — | — | CN | disclosed |
| EP-1682515-B1 | METHOD FOR THE PRODUCTION OF FLUOROMETHYL-SUBSTITUTED HETEROCYCLES | BAYER CROPSCIENCE AG (DE) | 2014-10-01 | — | — | EP | disclosed |
| CN-103582631-A | Method for preparing a fluorinated organic compound | RHODIA OPERATIONS | 2014-02-12 | — | — | CN | disclosed |
| EP-1678119-B1 | METHOD FOR PRODUCING 2-DIHALOACYL-3-AMINO-ACRYLIC ACID ESTERS AND 3-DIHALOMETHYL-PYRAZOLE-4-CARBOXYLIC ACID ESTERS | BAYER CROPSCIENCE AG (DE) | 2011-01-05 | — | — | EP | disclosed |
| US-7501527-B2 | Method for the production of fluoromethyl-substituted heterocycles | BAYER CROPSCIENCE GMBH (DE) | 2009-03-10 | — | — | US | disclosed |
| US-7501527-B2 | Method for the production of fluoromethyl-substituted heterocycles | BAYER CROPSCIENCE GMBH (DE) | 2009-03-10 | — | — | US | disclosed |
| US-7358387-B2 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-7358387-B2 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-7358387-B2 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AG (DE) | 2008-04-15 | — | — | US | disclosed |
| US-20060276656-A1 | Method for the production of fluoromethyl-substituted heterocycles | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-12-07 | — | — | US | disclosed |
| US-20060252944-A1 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276656-A1 | Method for the production of fluoromethyl-substituted heterocycles | FLI1, CBR3, CBR1 | BAZ2B 3142/4885BAZ2A 3559/4885ADORA3 1563/4885 |
| US-20060252944-A1 | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl pyrazole-4-carboxylic acid esters | DDC, IDUA, AADAT | BAZ2B 1400/4885BAZ2A 1479/4885ADORA3 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.