Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | SPR | P35270 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518930 | 0.86 | SPR (0.55) | RAB9ASMN1; SMN2PDE5ASPRMAPT | |
| SCHEMBL22287932 | 0.74 | RAB9A (0.54) | RAB9ASMN1; SMN2PDE5ASPRRXFP1 | |
| SCHEMBL28051087 | 0.73 | GUSB (0.61) | RAB9ASMN1; SMN2PDE5ASPRMAPT | |
| SCHEMBL13789347 | 0.72 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2PDE5ASPRMAPT | |
| SCHEMBL4503183 | 0.72 | KMT2A (0.34) | RAB9ASMN1; SMN2RXFP1MAPTRHEB | |
| SCHEMBL30577613 | 0.72 | NQO2 (0.46) | RAB9ASMN1; SMN2RXFP1MAPTL3MBTL1 | |
| SCHEMBL29398836 | 0.70 | KDM4E (0.57) | RAB9ASMN1; SMN2PDE5ASPRRXFP1 | |
| SCHEMBL5482863 | 0.70 | PDE5A (0.72) | RAB9ASMN1; SMN2PDE5ASPRRXFP1 | |
| SCHEMBL13789326 | 0.69 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2PDE5ASPRMAPT | |
| SCHEMBL13789304 | 0.69 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2PDE5ASPRRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557112-B2 | Aromatic-ring-fused pyrimidine derivative | ASTELLAS PHARMA INC. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20070249587-A1 | Aromatic-Ring-Fused Pyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1806347-A1 | AROMATIC-RING-FUSED PYRIMIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2007-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249587-A1 | Aromatic-Ring-Fused Pyrimidine Derivative | GPR119, NOD1, IRS1 | RAB9A 3054/4885SMN1; SMN2 2701/4885PDE5A 2503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.