Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507491 | 0.84 | MIF (0.54) | POLBLMNAMEN1KMT2AMAPT | |
| SCHEMBL4376098 | 0.81 | ALDH1A1 (0.57) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4496903 | 0.77 | MIF (0.55) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4518177 | 0.75 | GRIN1 (0.48) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1641954 | 0.74 | APLNR (0.45) | POLBAPLNRMEN1KMT2AALDH1A1 | |
| SCHEMBL4512432 | 0.73 | POLB (0.47) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4501972 | 0.73 | POLB (0.47) | POLBLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL23120458 | 0.72 | APLNR (0.48) | POLBAPLNRMEN1KMT2AALDH1A1 | |
| SCHEMBL19577093 | 0.72 | APLNR (0.48) | POLBLMNAAPLNRMEN1KMT2A | |
| SCHEMBL26857663 | 0.72 | ALDH1A1 (0.47) | POLBAPLNRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | POLB 619/4885LMNA 2954/4885APLNR 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.