Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620078 | 0.96 | BCL2 (0.43) | BCL2MCL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4534920 | 0.79 | BCL2 (0.47) | BCL2MCL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4528286 | 0.74 | LMNA (0.63) | BCL2MCL1LMNAMAPTSIRT1 | |
| SCHEMBL2417465 | 0.73 | GABRA1 (0.70) | BCL2MCL1SMN1; SMN2LMNAGABRA1 | |
| SCHEMBL4070902 | 0.73 | LMNA (0.53) | BCL2MCL1LMNASIRT1MAPK1 | |
| SCHEMBL4534427 | 0.72 | BCL2 (0.41) | BCL2MCL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL15214045 | 0.69 | NR4A1 (0.61) | BCL2MCL1MAPTGABRA1GABRB1 | |
| SCHEMBL2417564 | 0.67 | GABRA1 (0.64) | BCL2MCL1SMN1; SMN2LMNAGABRA1 | |
| SCHEMBL4240599 | 0.67 | POLB (0.59) | BCL2MCL1LMNAMAPTRAB9A | |
| SCHEMBL11445915 | 0.66 | NR4A1 (0.49) | SMN1; SMN2LMNAMAPTMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270470-A1 | Compounds I | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | claimed |
| EP-1881950-A1 | NEW COMPOUNDS I | AstraZeneca AB (SE) | 2008-01-30 | — | — | EP | claimed |
| WO-2006121391-A1 | NEW COMPOUNDS I | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | claimed |
| US-20090270470-A1 | Compounds I | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | disclosed |
| EP-1881950-A1 | NEW COMPOUNDS I | AstraZeneca AB (SE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006121391-A1 | NEW COMPOUNDS I | ASTRAZENECA AB (SE) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270470-A1 | Compounds I | F12, F11, F5 | BCL2 3078/4885MCL1 1018/4885SMN1; SMN2 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.