Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249427 | 0.87 | NPC1 (0.63) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL28292159 | 0.83 | POLB (0.46) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL29229971 | 0.81 | POLB (0.64) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL4242596 | 0.79 | RORC (0.41) | POLBMAPTHPGDNPC1LPAR1 | |
| SCHEMBL4240485 | 0.78 | CES2 (0.54) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL7410935 | 0.77 | POLB (0.62) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL7051707 | 0.75 | NR3C1 (0.74) | POLBMAPT | |
| SCHEMBL17948554 | 0.75 | CYP3A4 (0.47) | POLBMAPTHTTNPSR1HPGD | |
| SCHEMBL382778 | 0.75 | HPGD (0.55) | POLBMAPTNPSR1HPGDALDH1A1 | |
| SCHEMBL4070902 | 0.75 | LMNA (0.53) | POLBCNR1LMNABCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066060-A2 | 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE | TOPOTARGET A/S (DK) | 2009-05-28 | — | — | WO | disclosed |