Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.82 |
| ▸ | MEN1 | O00255 | 14/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.82 |
| ▸ | GAA | P10253 | 10/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.82 |
| ▸ | HTT | P42858 | 9/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | LMNA | P02545 | 8/20 | 0.82 |
| ▸ | HPGD | P15428 | 5/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | MMP9 | P14780 | 1/20 | 0.77 |
| ▸ | CFTR | P13569 | 4/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14132670 | 0.92 | MMP9 (0.77) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6114069 | 0.91 | MMP9 (0.78) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL19652440 | 0.90 | MEN1 (0.86) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL14058944 | 0.89 | MMP9 (0.79) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL14054038 | 0.89 | MEN1 (0.83) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6113962 | 0.89 | MMP9 (0.75) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL14133178 | 0.89 | MMP9 (0.75) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL8739510 | 0.89 | MMP9 (0.74) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6114320 | 0.89 | MMP9 (0.74) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| Bromide SCHEMBL14053685 | 0.89 | MMP9 (0.77) | MAPTMEN1KMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | claimed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | claimed |
| EP-1709019-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2007-08-08 | — | — | EP | claimed |
| JP-2007517835-A | — | — | 2007-07-05 | — | — | JP | claimed |
| EP-1709019-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2006-10-11 | — | — | EP | claimed |
| WO-2005068444-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-07-28 | — | — | WO | claimed |
| US-9150561-B2 | Thiazole derivatives and use thereof | MERCK SERONO S.A. (CH) | 2015-10-06 | — | — | US | disclosed |
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
| US-8802861-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2014-08-12 | — | — | US | disclosed |
| US-20120302573-A1 | METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | US | disclosed |
| US-20120302573-A1 | METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | US | disclosed |
| US-20120302573-A1 | METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | US | disclosed |
| WO-2012162468-A1 | THIAZOL DERIVATIVES AS PRO -MATRIX METALLOPROTEINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-11-29 | — | — | WO | disclosed |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2009-01-29 | — | — | US | disclosed |
| EP-1709019-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2007-08-08 | — | — | EP | disclosed |
| EP-1709019-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068444-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | MAPT 4151/4885MEN1 1164/4885KMT2A 4760/4885 |
| US-20120302573-A1 | METHODS OF INHIBITING PRO MATRIX METALLOPROTEINASE ACTIVATION | MMP13, MMP8, MMP11 | MAPT 4402/4885MEN1 2970/4885KMT2A 4146/4885 |
| US-20090029998-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | MAPT 1418/4885MEN1 1761/4885KMT2A 4737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.