Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 3/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323509 | 0.83 | KCNQ2 (0.50) | KCNQ2CRHBPCRHR2ALDH1A1LMNA | |
| SCHEMBL6937634 | 0.82 | ALDH1A1 (0.59) | KCNQ2CRHBPCRHR2ALDH1A1LMNA | |
| SCHEMBL27515059 | 0.80 | FFAR2 (0.48) | FFAR2KCNQ2L3MBTL1LMNAHTT | |
| SCHEMBL23564521 | 0.80 | FFAR2 (0.48) | FFAR2KCNQ2L3MBTL1LMNAHTT | |
| SCHEMBL9588276 | 0.78 | FFAR2 (0.49) | FFAR2KCNQ2CRHBPCRHR2L3MBTL1 | |
| SCHEMBL16075922 | 0.78 | POLB (0.58) | FFAR2KCNQ2CRHBPCRHR2LMNA | |
| SCHEMBL1742115 | 0.78 | POLB (0.58) | FFAR2KCNQ2CRHBPCRHR2LMNA | |
| SCHEMBL7711076 | 0.78 | POLB (0.58) | FFAR2KCNQ2CRHBPCRHR2LMNA | |
| SCHEMBL2117010 | 0.77 | EGFR (0.49) | KCNQ2CRHBPCRHR2ALDH1A1LMNA | |
| SCHEMBL7629387 | 0.77 | L3MBTL1 (0.61) | FFAR2KCNQ2L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | NEUROSEARCH A/S (DK) | 2009-11-26 | — | — | US | disclosed |
| EP-1951685-A1 | NOVEL QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007057447-A1 | NOVEL QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291973-A1 | Novel Quinazoline Derivatives and Their Medical Use | KCNA7, KCNN3, KCNQ5 | FFAR2 2339/4885KCNQ2 12/4885CRHBP 4427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.