Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | WNT3A | P56704 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741788 | 0.81 | KCNJ5 (0.65) | ROCK2ROCK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL19827071 | 0.77 | MEN1 (0.73) | ROCK2ROCK1MEN1KMT2AWNT3A | |
| SCHEMBL4525615 | 0.77 | WNT3A (0.44) | ROCK2ROCK1MEN1KMT2AWNT3A | |
| SCHEMBL4516268 | 0.76 | ROCK2 (0.57) | ROCK2ROCK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4525608 | 0.75 | ROCK2 (0.46) | ROCK2ROCK1MEN1KMT2AWNT3A | |
| SCHEMBL8331684 | 0.75 | MEN1 (0.79) | MEN1KMT2AWNT3ASMN1; SMN2POLB | |
| SCHEMBL4631344 | 0.74 | NOTUM (0.67) | ROCK2ROCK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4630248 | 0.73 | PORCN (0.46) | ROCK2ROCK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4518077 | 0.73 | PORCN (0.64) | ROCK2ROCK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14605463 | 0.73 | ROCK2 (0.67) | ROCK2ROCK1ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885MEN1 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.