Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522170 | 1.00 | HPGD (0.47) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4511815 | 0.83 | HPGD (0.52) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4511823 | 0.83 | HPGD (0.52) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4515539 | 0.78 | KMT2A (0.39) | HPGDALDH1A1AGBL2KMT2AKDM4E | |
| SCHEMBL24674722 | 0.75 | ALDH1A1 (0.38) | ALDH1A1AGBL2KMT2ARAB9AKDM4E | |
| SCHEMBL5717499 | 0.74 | ALDH1A1 (0.62) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL26634016 | 0.73 | RAB9A (0.55) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1124418 | 0.72 | KMT2A (0.53) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1124416 | 0.72 | KMT2A (0.53) | HPGDCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL24968193 | 0.72 | RAB9A (0.47) | HPGDCYP2C9ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | BROWN REBECCA ELIZABETH | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298856-A1 | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) | TRPV1, TRPV2, TRPV4 | HPGD 621/4885CYP1A2 1418/4885CYP2C9 2186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.