Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.49 |
| ▸ | HTR3B | O95264 | 4/20 | 0.49 |
| ▸ | HTR3A | P46098 | 4/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355641 | 0.89 | JAK3 (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6500066 | 0.85 | JAK3 (0.41) | ALDH1A1CYP1A2MAPK1TDP1HRH4 | |
| SCHEMBL942469 | 0.81 | PIK3CB (0.51) | HTT | |
| SCHEMBL3254758 | 0.77 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30208796 | 0.73 | JAK3 (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6066498 | 0.72 | ROCK2 (0.38) | CYP3A4HTTTHPO | |
| SCHEMBL31434932 | 0.72 | JAK3 (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL18163265 | 0.70 | PARP1 (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1559213 | 0.69 | PLD1 (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30146590 | 0.69 | HTR3E (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281083-A1 | Combination Product | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | US | disclosed |
| EP-1874774-A1 | COMBINATION PRODUCT | AstraZeneca AB (SE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006112772-A1 | COMBINATION PRODUCT | ASTRAZENECA AB (SE) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281083-A1 | Combination Product | PAH, PTGIS, CYP11B2 | HTR3E 1210/4885HTR3B 446/4885HTR3A 1363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.