Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.54 |
| ▸ | HTR3B | O95264 | 4/20 | 0.54 |
| ▸ | HTR3A | P46098 | 4/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417015 | 0.86 | JAK3 (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL16417007 | 0.84 | JAK3 (0.45) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4975825 | 0.84 | JAK3 (0.45) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL16417018 | 0.81 | HTR3A (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5413458 | 0.81 | PIK3CA (0.50) | KDM4EHTT | |
| SCHEMBL4524341 | 0.77 | HTR3E (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21268754 | 0.74 | ADRB1 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30945083 | 0.73 | ROCK2 (0.50) | HTR2CALDH1A1CYP3A4KDM4ECYP1A2 | |
| SCHEMBL16720137 | 0.73 | AXL (0.42) | — | |
| SCHEMBL30376196 | 0.72 | MAP3K11 (0.66) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971605-B1 | PYRROLO [2 , 3-B] PYRIDINE DERIVATIVES AS H3 RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | disclosed |
| CN-101331131-A | Pyrrolo [2, 3-b] pyridine derivatives as h3 receptor modulators | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | CN | disclosed |
| EP-1971605-A1 | PYRROLO [2 , 3-B] PYRIDINE DERIVATIVES AS H3 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-24 | — | — | EP | disclosed |
| US-7351708-B2 | Pyrrolo [2,3-b] pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-04-01 | — | — | US | disclosed |
| WO-2007068641-A1 | PYRROLO [2 , 3-B] PYRIDINE DERIVATIVES AS H3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-21 | — | — | WO | disclosed |
| US-20070142358-A1 | Pyrrolo [2,3-B] pyridine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142358-A1 | Pyrrolo [2,3-B] pyridine derivatives | HRH4, HRH3, HRH1 | HTR3E 285/4885HTR3B 228/4885HTR3A 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.