Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28067641 | 0.87 | MAPT (0.44) | NOTUMMAPTNPSR1SMN1; SMN2SLC18A3 | |
| SCHEMBL28782710 | 0.76 | NOTUM (0.40) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL5702158 | 0.75 | NOTUM (0.49) | NOTUMSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5702089 | 0.75 | NOTUM (0.49) | NOTUMSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9668731 | 0.74 | MAPT (0.52) | MAPTNPSR1SMN1; SMN2SLC18A3MAPK1 | |
| SCHEMBL23198268 | 0.74 | AGTR2 (0.44) | NOTUMMAPTNPSR1MAPK1HTT | |
| SCHEMBL20141927 | 0.74 | AGTR2 (0.44) | NOTUMMAPTNPSR1MAPK1HTT | |
| SCHEMBL20141914 | 0.74 | AGTR2 (0.44) | NOTUMMAPTNPSR1MAPK1HTT | |
| SCHEMBL4799232 | 0.73 | NOTUM (0.43) | NOTUMMAPTSMN1; SMN2SLC18A3HTT | |
| SCHEMBL4799227 | 0.73 | NOTUM (0.43) | NOTUMMAPTSMN1; SMN2SLC18A3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094375-B | Blocking agent dissociation catalyst for blocked isocyanate and thermosetting composition containing the same | 广荣化学株式会社 | 2022-04-01 | — | — | CN | disclosed |
| EP-2051955-B1 | PRODUCTION OF ALPHA HYDROXY KETONES VIA CARBENE CATALYZED POLE REVERSAL REACTION OF ALDEHYDES | EVONIK DEGUSSA GMBH (DE) | 2016-08-31 | — | — | EP | disclosed |
| CN-102993072-A | Method for producing methionine | SUMITOMO CHEMICAL CO | 2013-03-27 | — | — | CN | disclosed |
| US-7504542-B2 | Preparation of α-hydroxy ketones via carbene-catalyzed umpolung reaction of aldehydes | EVONIK DEGUSSA GMBH (DE) | 2009-03-17 | — | — | US | disclosed |
| US-20080051608-A1 | Preparation of alpha-hydroxy ketones via carbene-catalyzed umpolung reaction of aldehydes | DEGUSSA GMBH (DE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051608-A1 | Preparation of alpha-hydroxy ketones via carbene-catalyzed umpolung reaction of aldehydes | HACL2, PCCA, ECI1 | NOTUM 353/4885MAPT 4034/4885NPSR1 4529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.