Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799227 | 1.00 | NOTUM (0.43) | NOTUMHRH3SLC18A3KMT2AKDM4E | |
| SCHEMBL10839714 | 0.88 | HRH3 (0.40) | NOTUMHRH3SLC18A3KMT2AKDM4E | |
| SCHEMBL10839827 | 0.87 | KDM4E (0.41) | HRH3KMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL10839275 | 0.85 | HRH3 (0.38) | NOTUMHRH3SLC18A3KMT2AKDM4E | |
| SCHEMBL10839670 | 0.85 | MEN1 (0.39) | NOTUMHRH3SLC18A3KMT2AALDH1A1 | |
| SCHEMBL4801000 | 0.85 | AGTR2 (0.42) | HRH3SLC18A3KMT2AKDM4EALDH1A1 | |
| SCHEMBL10839706 | 0.82 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL4799260 | 0.79 | ALDH1A1 (0.39) | KMT2AKDM4EALDH1A1MEN1POLB | |
| SCHEMBL14180297 | 0.79 | KDM2B (0.45) | KMT2AKDM4EALDH1A1MEN1FFAR1 | |
| SCHEMBL10838330 | 0.78 | HPGD (0.35) | HRH3SLC18A3KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200417-B1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | claimed |
| EP-1200417-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2002-05-02 | — | — | EP | claimed |
| WO-2001004105-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2001-01-18 | — | — | WO | claimed |
| US-7378521-B2 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2008-05-27 | — | — | US | disclosed |
| US-20070167623-A1 | PREPARATION OF 2-(2-ARYLMORPHOLIN-2-YL) ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-AVENTIS (FR) | 2007-07-19 | — | — | US | disclosed |
| US-7223860-B2 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2007-05-29 | — | — | US | disclosed |
| US-20060149058-A1 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2006-07-06 | — | — | US | disclosed |
| US-7038044-B1 | Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates | SANOFI-AVENTIS (FR) | 2006-05-02 | — | — | US | disclosed |
| EP-1200417-B1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI SYNTHELABO (FR) | 2003-10-22 | — | — | EP | disclosed |
| EP-1200417-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001004105-A1 | METHOD FOR PREPARING 2-(2-ARYLMORPHOLIN-2-YL)ETHANOL DERIVATIVES AND INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2001-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167623-A1 | PREPARATION OF 2-(2-ARYLMORPHOLIN-2-YL) ETHANOL DERIVATIVES AND INTERMEDIATES | ADH1C, ADH1A, ADH5 | NOTUM 42/4885HRH3 325/4885SLC18A3 471/4885 |
| US-20060149058-A1 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates | ADH1C, ADH1A, ADH5 | NOTUM 42/4885HRH3 325/4885SLC18A3 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.