Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.72 |
| ▸ | HTR5A | P47898 | 2/20 | 0.72 |
| ▸ | NCF1 | P14598 | 2/20 | 0.72 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.72 |
| ▸ | HTR3B | O95264 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | HTR1D | P28221 | 1/20 | 0.72 |
| ▸ | HTR1B | P28222 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | HTR7 | P34969 | 1/20 | 0.72 |
| ▸ | MTOR | P42345 | 1/20 | 0.72 |
| ▸ | HTR3A | P46098 | 1/20 | 0.72 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.72 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5254026 | 0.86 | HTR5A (0.59) | HTR6HTR5ANCF1HTR3EHTR3B | |
| SCHEMBL29385724 | 0.85 | HTR6 (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| SCHEMBL3166780 | 0.85 | HTR6 (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| SCHEMBL240244 | 0.85 | HTR6 (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL25379293 | 0.83 | LMNA (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL27664894 | 0.83 | LMNA (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL466870 | 0.83 | LMNA (1.00) | HTR6HTR5ANCF1HTR3EHTR3B | |
| Trifluoroacetic Acid SCHEMBL30839779 | 0.80 | BACE1 (0.46) | HTR6HTR5ANCF1HTR3EHTR3B | |
| Trifluoroacetic Acid SCHEMBL30839757 | 0.80 | ADRB1 (0.74) | HTR6 | |
| SCHEMBL7719591 | 0.79 | HTR6 (0.87) | HTR6HTR5ANCF1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
| CN-101137645-A | Arylpiperazine derivatives for the treatment of neuropsychiatric disorders | UNIV SIENA (IT) | 2008-03-05 | — | — | CN | disclosed |
| EP-1836192-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Universita' Degli Studi di Siena (IT) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072608-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | UNIVERSITÁ DEGLI STUDI DI SIENA (IT) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | HTR6 16/4885HTR5A 8/4885NCF1 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.