Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GGT1 | P19440 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293803 | 0.87 | LMNA (0.38) | KMT2AMEN1ALDH1A1CYP1A2ALOX15 | |
| Trifluoroacetic Acid SCHEMBL29886945 | 0.85 | NOS1 (0.37) | NOS1NOS2KMT2AGGT1MEN1 | |
| Hydrochloric Acid SCHEMBL6214815 | 0.84 | LMNA (0.36) | KMT2AMEN1ALDH1A1CYP1A2ALOX15 | |
| SCHEMBL1106837 | 0.82 | ACLY (0.43) | KMT2AGGT1MEN1ALDH1A1CYP1A2 | |
| Succinamide SCHEMBL27483865 | 0.79 | ALOX15 (0.39) | NOS1NOS2KMT2AMEN1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL30169296 | 0.77 | SLC22A6 (0.38) | NOS1NOS2KMT2AMEN1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL30882498 | 0.77 | SLC22A6 (0.38) | NOS1NOS2KMT2AMEN1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5069426 | 0.76 | FFAR3 (0.42) | NOS1NOS2KMT2AMEN1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7045090 | 0.76 | FFAR3 (0.42) | NOS1NOS2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1030177 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326003-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326003-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE12 | NOS1 359/4885NOS2 552/4885KMT2A 2872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.