Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539274 | 0.95 | CYP3A4 (0.51) | CYP3A4CYP2C19MAPTKMT2AEPHX1 | |
| SCHEMBL4539395 | 0.90 | LMNA (0.47) | CYP3A4CYP2C19KMT2AEPHX1MEN1 | |
| SCHEMBL4537575 | 0.90 | ALDH1A1 (0.49) | CYP3A4CYP2C19KMT2AEPHX1LMNA | |
| SCHEMBL4537343 | 0.90 | LMNA (0.59) | CYP3A4CYP2C19KMT2AEPHX1MEN1 | |
| SCHEMBL4537427 | 0.90 | SMN1; SMN2 (0.52) | CYP3A4CYP2C19KMT2AEPHX1LMNA | |
| SCHEMBL4536795 | 0.89 | EPHX1 (0.54) | KMT2AEPHX1LMNAALDH1A1HTT | |
| SCHEMBL4537319 | 0.87 | ALDH1A1 (0.52) | EPHX1TP53LMNAALDH1A1HTT | |
| SCHEMBL4542921 | 0.86 | CYP3A4 (0.57) | CYP3A4CYP2C19MAPTKMT2ACYP19A1 | |
| SCHEMBL8069615 | 0.86 | EPHX1 (0.47) | CYP3A4CYP2C19KMT2AEPHX1MEN1 | |
| SCHEMBL4542516 | 0.85 | LMNA (0.49) | KMT2AEPHX1MEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |