Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25904014 | 0.81 | TDP1 (0.51) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL3984862 | 0.77 | HTR7 (0.36) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL7816219 | 0.77 | GAA (0.68) | HSD17B10GAAALOX5MEN1KMT2A | |
| SCHEMBL4377509 | 0.73 | KDM4E (0.58) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL26989629 | 0.73 | CYP1A2 (0.54) | CYP1A2CYP2D6CYP2C9CYP2C19TDP1 | |
| SCHEMBL22074044 | 0.71 | MAPT (0.48) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL25903509 | 0.70 | ALOX5 (0.45) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL25904050 | 0.70 | GAA (0.53) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL19193144 | 0.69 | HTR7 (0.53) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 | |
| SCHEMBL6981457 | 0.69 | HTR2C (0.77) | CYP1A2CYP2D6CYP2C9HTR1DCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | CYP1A2 534/4885CYP2D6 500/4885CYP2C9 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.