Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.45 |
| ▸ | TLR3 | O15455 | 1/20 | 0.45 |
| ▸ | TLR5 | O60602 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.45 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.45 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.45 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.45 |
| ▸ | MGMT | P16455 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512860 | 0.91 | DHFR (0.50) | TLR8DHFR | |
| SCHEMBL4536401 | 0.86 | HSP90AA1 (0.47) | TLR8DHFRHTT | |
| SCHEMBL4107331 | 0.83 | TLR4 (0.47) | DCPSBRD4TLR4TLR3TLR5 | |
| SCHEMBL3766518 | 0.83 | MGMT (0.47) | DCPSBRD4TLR4TLR3TLR5 | |
| SCHEMBL4511575 | 0.82 | XDH (0.46) | MGMTMPOTPOCYP3A4EPX | |
| SCHEMBL4107496 | 0.82 | DCPS (0.48) | DCPSBRD4TLR4TLR3TLR5 | |
| SCHEMBL4108287 | 0.82 | DCPS (0.48) | DCPSBRD4TLR4TLR3TLR5 | |
| SCHEMBL4534714 | 0.81 | ADORA2A (0.42) | TLR8MPODHFRCDK1CCNB1 | |
| SCHEMBL4113986 | 0.81 | MPO (0.48) | DCPSMGMTMPOTPOCYP3A4 | |
| SCHEMBL4522776 | 0.80 | L3MBTL1 (0.54) | TLR8MPODHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232278-B2 | Pyrido(3,2-D)pyrimidines and pharmaceutical compositions useful for treating hepatitis C | GILEAD SCIENCES, INC. (US) | 2012-07-31 | — | — | US | claimed |
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | GILEAD SCIENCES, INC. (US) | 2009-05-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131414-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C | DPYD, TYMP, PNPO | DCPS 257/4885BRD4 2153/4885TLR4 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.