Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542459 | 0.97 | P2RX7 (0.42) | HSD11B1P2RX7HPGD | |
| SCHEMBL8063845 | 0.91 | HSD11B1 (0.44) | HSD11B1P2RX7ALDH1A1 | |
| SCHEMBL4537224 | 0.89 | P2RX7 (0.43) | P2RX7LMNA | |
| SCHEMBL8058698 | 0.88 | KMT2A (0.44) | P2RX7HPGDALDH1A1KMT2AMCOLN3 | |
| SCHEMBL4533522 | 0.88 | KMT2A (0.44) | P2RX7HPGDALDH1A1KMT2AMCOLN3 | |
| SCHEMBL4539750 | 0.88 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL4531591 | 0.87 | DRD2 (0.42) | HSD11B1P2RX7HPGD | |
| SCHEMBL8069525 | 0.87 | EPHX2 (0.45) | HSD11B1KMT2A | |
| SCHEMBL4537337 | 0.87 | ATM (0.46) | HSD11B1HPGDLMNAGAAALDH1A1 | |
| SCHEMBL4534763 | 0.87 | EPHX1 (0.52) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |