Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533522 | 1.00 | KMT2A (0.44) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL4537324 | 0.97 | MEN1 (0.47) | KMT2AMEN1L3MBTL1NPC1RAB9A | |
| SCHEMBL4531364 | 0.88 | HSD11B1 (0.44) | KMT2AALDH1A1MCOLN3P2RX7HPGD | |
| SCHEMBL4537337 | 0.87 | ATM (0.46) | KMT2ARAB9AALDH1A1MCOLN3HPGD | |
| SCHEMBL4537565 | 0.86 | RAB9A (0.51) | NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL4542459 | 0.85 | P2RX7 (0.42) | P2RX7HPGD | |
| SCHEMBL4535257 | 0.84 | RAB9A (0.53) | RAB9AALDH1A1 | |
| SCHEMBL4537759 | 0.84 | RAB9A (0.45) | NPC1RAB9A | |
| SCHEMBL4539750 | 0.84 | HSD11B1 (0.52) | — | |
| SCHEMBL4530191 | 0.83 | EPHX2 (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |