Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24661857 | 0.92 | KDM4E (0.48) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL15928723 | 0.92 | KDM4E (0.48) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL21799663 | 0.90 | KDM4E (0.50) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL29922322 | 0.90 | KDM4E (0.50) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL4069931 | 0.87 | DDB1 (0.48) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL15289750 | 0.84 | KDM4E (0.46) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL1197844 | 0.84 | POLB (0.54) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL19675712 | 0.81 | DDB1 (0.43) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL4066935 | 0.80 | HTR6 (0.47) | KDM4EMAPTTDP1GAAMEN1 | |
| SCHEMBL22694536 | 0.79 | KDM4E (0.51) | KDM4EMEN1KMT2ADDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773274-A | Novel 4, 6-pyrimidine derivatives and application thereof in antitumor drugs | 四川大学华西医院 | 2022-07-22 | — | — | CN | disclosed |
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
| EP-1802608-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040526-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | KDM4E 2349/4885MAPT 3649/4885TDP1 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.