SCHEMBL453482

SCHEMBL453482

CN1CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(O)c21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
HIF1A Q16665 2/20 0.46
STAT6 P42226 2/20 0.46
CYP1A2 P05177 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
TP53 P04637 1/20 0.46
ALOX15 P16050 1/20 0.46
HTT P42858 1/20 0.46
HSD17B10 Q99714 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
CDA P32320 4/20 0.41
ADK P55263 1/20 0.41
SLC29A1 Q99808 2/20 0.40
DPP4 P27487 1/20 0.40
MEN1 O00255 1/20 0.40
SLC28A1 O00337 1/20 0.40
MAP3K7 O43318 1/20 0.40
SLC28A2 O43868 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL453483 1.00 MAPK1 (0.46) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL830795 0.87 MAPK1 (0.50) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL830796 0.87 MAPK1 (0.50) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL1527222 0.83 CDA (0.39) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL29267975 0.82 SLC29A1 (0.42) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL5584357 0.82 CASP6 (0.52) ADORA1SMN1; SMN2
SCHEMBL7744286 0.81 ALDH1A1 (0.39) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL8805090 0.80 CDK5 (0.41) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL7744270 0.80 MAPK1 (0.40) MAPK1TDP1HIF1ASTAT6CYP1A2
SCHEMBL9243746 0.79 ADORA1 (0.39) MAPK1TDP1HIF1ASTAT6CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3544 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
EP-4705481-A2 CIRCULAR RNA COMPOSITIONS AND METHODS Orna Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-20250345406-A1 CHIMERIC PROTEINS IN AUTOIMMUNITY SHATTUCK LABS INC (US) 2025-11-13 US claimed
US-20250325494-A1 COMPOSITION FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACID THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-10-23 US claimed
EP-4634380-A1 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-10-22 EP claimed
WO-2025151711-A1 NUCLEIC ACID VACCINES TARGETING METHANOGENS Arkea Bio Corp. (US) 2025-07-17 WO claimed
US-20250188013-A1 LIPID COMPOUND AND USE THEREOF THEMEDIUM THERAPEUTICS CO., LTD. (CN) 2025-06-12 US claimed
WO-2025122721-A1 CHIMERIC PROTEINS AND USES THEREOF SHATTUCK LABS, INC. (US) 2025-06-12 WO claimed
EP-4565692-A2 INTERNAL RIBOSOME ENTRY SITES FOR IMPROVED POLYNUCLEOTIDE TRANSLATION ModernaTX, Inc. (US) 2025-06-11 EP claimed
EP-4554616-A1 COMPOSITIONS AND METHODS FOR REDUCING METHANE EMISSIONS IN RUMINANT POPULATIONS Arkea Bio Corp. (US) 2025-05-21 EP claimed
WO-2013039861-A2 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF modeRNA Therapeutics (US) 2013-03-21 WO claimed
WO-2012158736-A1 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF FOR NON-HUMAN VERTEBRATES modeRNA Therapeutics (US) 2012-11-22 WO claimed
US-20120251618-A1 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 US claimed
WO-2012135805-A2 DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS modeRNA Therapeutics (US) 2012-10-04 WO claimed
CN-1440749-A Edaravone injection for treating acute cerebral thrombus and its prepn HONGYI SCI TECH CO LTD NANCHAN (CN) 2003-09-10 CN claimed
US-6274314-B1 Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine NYXIS NEUROTHERAPIES, INC. 2001-08-14 US claimed
US-20010000078-A1 Diagnostic modified-nucleoside detection assay MOSKAL JOSEPH R (US) 2001-03-29 US claimed
WO-1999051985-A1 DIAGNOSTIC MODIFIED-NUCLEOSIDE DETECTION ASSAY CHICAGO INSTITUTE OF NEUROSURGERY AND NEURORESEARCH (US) 1999-10-14 WO claimed
US-5075225-A PROCESS FOR THE ENZYMATIC SYNTHESIS OF NUCLEOSIDES THE TEXAS A&M UNIVERSITY SYSTEM (US) 1991-12-24 US claimed
EP-0391592-A1 Process for the enzymatic synthesis of nucleosides THE TEXAS A & M UNIVERSITY SYSTEM (US) 1990-10-10 EP claimed