SCHEMBL9243746

SCHEMBL9243746

O=P(O)(O)ON1CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(O)c21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 1/20 0.39
HPRT1 P00492 1/20 0.39
CDA P32320 4/20 0.38
HIF1A Q16665 2/20 0.38
MAPK1 P28482 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HTT P42858 2/20 0.37
CYP1A2 P05177 1/20 0.37
STAT6 P42226 1/20 0.37
TP53 P04637 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
CASP6 P55212 1/20 0.37
MAPT P10636 1/20 0.37
ADK P55263 1/20 0.37
GAA P10253 1/20 0.36
BLM P54132 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9241942 0.92 P2RY2 (0.39) ADORA1HPRT1CDAHIF1AMAPK1
SCHEMBL9240204 0.90 P2RY2 (0.40) ADORA1ALDH1A1SMN1; SMN2
SCHEMBL453483 0.79 MAPK1 (0.46) ADORA1CDAHIF1AMAPK1TDP1
SCHEMBL453482 0.79 MAPK1 (0.46) ADORA1CDAHIF1AMAPK1TDP1
SCHEMBL5584357 0.76 CASP6 (0.52) ADORA1HPRT1CASP6SMN1; SMN2FBP1
SCHEMBL7744286 0.75 ALDH1A1 (0.39) ADORA1CDAHIF1AMAPK1TDP1
SCHEMBL8805090 0.74 CDK5 (0.41) ADORA1HIF1AMAPK1TDP1KDM4E
SCHEMBL7744270 0.73 MAPK1 (0.40) CDAHIF1AMAPK1TDP1KDM4E
SCHEMBL8804156 0.73 KDM4E (0.38) CDAHIF1AMAPK1TDP1KDM4E
SCHEMBL6702778 0.72 HIF1A (0.42) ADORA1CDAHIF1AMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5422343-A Administering inosine, guanosine, adenosine, uridine, cytidine and/or their monophosphates(or mixtures) for methicillin-resistant staphylococcus aureus infections OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1995-06-06 US claimed
US-4758553-A Compositions of nucletic acid components for nutritional replenishment OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1988-07-19 US claimed
EP-0149775-A1 Compositions of nucleic acid components OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1985-07-31 EP claimed
US-5422343-A Administering inosine, guanosine, adenosine, uridine, cytidine and/or their monophosphates(or mixtures) for methicillin-resistant staphylococcus aureus infections OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1995-06-06 US disclosed
US-4758553-A Compositions of nucletic acid components for nutritional replenishment OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1988-07-19 US disclosed
EP-0149775-A1 Compositions of nucleic acid components OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 1985-07-31 EP disclosed