SCHEMBL4535102

SCHEMBL4535102

COc1ccccc1/C=C/C(=O)c1ccccc1OC

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 5/20 0.80
MAOB P27338 4/20 0.80
NR1H4 Q96RI1 3/20 0.74
ABCG2 Q9UNQ0 1/20 0.73
MAPT P10636 3/20 0.71
NPC1 O15118 2/20 0.71
LMNA P02545 2/20 0.71
BCHE P06276 1/20 0.71
RAB9A P51151 1/20 0.71
NFE2L2 Q16236 2/20 0.70
TFEB P19484 1/20 0.70
KDM4E B2RXH2 2/20 0.68
HPGD P15428 2/20 0.68
RECQL P46063 2/20 0.68
MEN1 O00255 1/20 0.68
ALDH1A1 P00352 1/20 0.68
POLB P06746 1/20 0.68
HTT P42858 1/20 0.68
KMT2A Q03164 1/20 0.68
CYP1A1 P04798 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5084268 0.89 AR (1.00) ARMAOBNR1H4ABCG2MAPT
SCHEMBL30807180 0.89 AR (1.00) ARMAOBNR1H4ABCG2MAPT
SCHEMBL15631497 0.89 ABCG2 (0.68) ARMAOBNR1H4ABCG2MAPT
SCHEMBL5084274 0.89 AR (1.00) ARMAOBNR1H4ABCG2MAPT
SCHEMBL1764951 0.88 NFE2L2 (0.70) ARMAOBNR1H4ABCG2MAPT
SCHEMBL21661955 0.88 AR (0.72) ARMAOBNR1H4MAPTNPC1
SCHEMBL7100046 0.88 AR (0.72) ARMAOBNR1H4ABCG2MAPT
SCHEMBL19423222 0.88 ABCG2 (0.74) ARMAOBNR1H4ABCG2MAPT
SCHEMBL30194637 0.86 AR (0.66) ARMAOBNR1H4ABCG2MAPT
SCHEMBL31167606 0.86 ABCG2 (0.77) ARMAOBNR1H4ABCG2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2025-08-14 US disclosed
CN-118894756-A Deoxidization and reduction method for alpha, beta unsaturated ketone 温州医科大学 2024-11-05 CN disclosed
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2024-08-29 US disclosed
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2024-04-09 US disclosed
WO-2023165870-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS ON BONE HEALTH Société des Produits Nestlé S.A. (CH) 2023-09-07 WO disclosed
WO-2023158383-A2 METHOD FOR CELLULAR LIFESPAN MEASUREMENT AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-08-24 WO disclosed
EP-2810198-B1 ANTI-INVASIVE COMPOUNDS UNIV GENT (BE) 2023-07-12 EP disclosed
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2022-05-19 US disclosed
EP-3986557-A1 COMPOSITIONS AND METHODS TO POTENTIATE MUSCULOSKELETAL EFFECT OF ONE OR MORE ANABOLIC AMINO ACIDS Société des Produits Nestlé S.A. (CH) 2022-04-27 EP disclosed
US-11266634-B2 Methods for treating melanoma with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2022-03-08 US disclosed
EP-1781305-A2 COMPOSITIONS AND METHODS USING HYALURONIC ACID AND HYALURONIDASE INHIBITORS ANGIOTECH INTERNATIONAL AG (CH) 2007-05-09 EP disclosed
EP-1748767-A1 DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES Unigen Pharmaceuticals, Inc. (US) 2007-02-07 EP disclosed
WO-2006127539-A1 USE OF CHALCONES FOR THE TREATMENT OF VIRAL DISORDERS JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2006-11-30 WO disclosed
WO-2006020994-A2 COMPOSITIONS AND METHODS USING HYALURONIC ACID AND HYLURONIDASE INHIBITORS ANGIOTECH INTERNATIONAL AG (CH) 2006-02-23 WO disclosed
WO-2005117849-A1 DIARYLALKANES AS POTENT INHIBITORS OF BINUCLEAR ENZYMES UNIGEN PHARMACEUTICALS, INC. (US) 2005-12-15 WO disclosed
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2005-07-07 US disclosed
EP-0661967-A1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS CENTER FOR INNOVATIVE TECHNOLOGY (US) 1995-07-12 EP disclosed
EP-0661967-A4 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS. UNIV VIRGINIA (US) 1994-09-29 EP disclosed
WO-1993009764-A1 COMBINED VIRUSTATIC ANTIMEDIATOR (COVAM) TREATMENT OF COMMON COLDS CENTER FOR INNOVATIVE TECHNOLOGY (US) 1993-05-27 WO disclosed
US-4863968-A Methods of treating gout with chalcone derivatives MERRELL DOW PHARMACEUTICALS INC. (US) 1989-09-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11266634-B2 Methods for treating melanoma with human therapeutic agents HNMT, INMT, TYR AR 4081/4885MAOB 361/4885NR1H4 4145/4885
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents MCL1, CD44, INMT AR 3990/4885MAOB 1982/4885NR1H4 2700/4885
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS INMT, NLN, MYC AR 3778/4885MAOB 823/4885NR1H4 4224/4885
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states FLT1, VEGFA, FLT4 AR 1367/4885MAOB 1509/4885NR1H4 1209/4885
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN AR 3053/4885MAOB 806/4885NR1H4 2294/4885
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS HASPIN, TIPARP, SHARPIN AR 4232/4885MAOB 2103/4885NR1H4 3441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.