Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HTR5A | P47898 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542494 | 1.00 | HTR7 (0.52) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4537661 | 0.97 | HTR1A (0.48) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4541345 | 0.89 | POLB (0.44) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4536998 | 0.89 | BDKRB1 (0.49) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4541024 | 0.88 | RAB9A (0.48) | EPHX2LMNARAB9AEPHX1BDKRB1 | |
| SCHEMBL4542819 | 0.88 | RAB9A (0.54) | EPHX2SMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4535169 | 0.88 | HTR7 (0.54) | HTR7EPHX2USP2LMNARAB9A | |
| SCHEMBL8058321 | 0.88 | HTR7 (0.46) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL8064947 | 0.87 | HTR1A (0.50) | HTR7HTR1BDRD3HTR1ADRD2 | |
| SCHEMBL4537195 | 0.87 | HTR1A (0.50) | HTR7HTR1BDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |