Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542205 | 0.89 | RAB9A (0.52) | RAB9AHCRTR1HCRTR2CNR2BDKRB1 | |
| SCHEMBL4535231 | 0.88 | HTR7 (0.52) | HTR7TMEM97RAB9AKMT2AEPHX2 | |
| SCHEMBL4542494 | 0.88 | HTR7 (0.52) | HTR7TMEM97RAB9AKMT2AEPHX2 | |
| SCHEMBL4536998 | 0.86 | BDKRB1 (0.49) | HTR7RAB9AHCRTR1HCRTR2MEN1 | |
| SCHEMBL4535199 | 0.86 | MMP1 (0.53) | RAB9AHCRTR1HCRTR2CNR2BDKRB1 | |
| SCHEMBL4541345 | 0.86 | POLB (0.44) | HTR7RAB9AKMT2AUSP2LMNA | |
| SCHEMBL4542819 | 0.85 | RAB9A (0.54) | RAB9AKMT2AEPHX2 | |
| SCHEMBL4537661 | 0.85 | HTR1A (0.48) | HTR7RAB9AKMT2AEPHX2USP2 | |
| SCHEMBL4536790 | 0.84 | BDKRB1 (0.53) | RAB9AHCRTR1HCRTR2KMT2AEPHX2 | |
| SCHEMBL4543050 | 0.83 | BDKRB1 (0.52) | RAB9AHCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |