Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 12/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537661 | 0.90 | HTR1A (0.48) | HTR7HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL8062136 | 0.90 | BDKRB1 (0.45) | BDKRB1 | |
| SCHEMBL4542494 | 0.88 | HTR7 (0.52) | HTR7HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL4535231 | 0.88 | HTR7 (0.52) | HTR7HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL8049742 | 0.85 | EPHX2 (0.39) | HTR7HTR1ADRD2HTR1DDRD3 | |
| SCHEMBL8062139 | 0.84 | RAB9A (0.43) | HTR7LMNA | |
| SCHEMBL8070991 | 0.84 | HSD11B1 (0.53) | — | |
| SCHEMBL4543050 | 0.80 | BDKRB1 (0.52) | BDKRB1USP2LMNA | |
| SCHEMBL4540868 | 0.79 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL4537242 | 0.79 | NPC1 (0.53) | EPHX2BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |